RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike on an hidden munitions depot in Syria operated by the IS group, as stated by the UK Ministry of Defence.
The facility, pinpointed through intelligence, was thought to be storing arms and explosives, the release indicated, and was situated in mountains just north of Palmyra in the heart of Syria.
"Our aircraft used precision-guided Paveway IV munitions to target a number of approach shafts down to the facility... early reports indicate the strike was effective," the MoD said.
There was no sign of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the ministry further stated.
The British jets were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as Daesh - imposed extremist governance over parts of Syria and Iraq until 2019.
"This operation shows our UK leadership, and commitment to work closely with our partners, to eliminate any resurgence of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary said.
UK warplanes have conducted overwatch operations over Syrian airspace to "forestall any attempted comeback" of the group following its military defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank every member of our armed forces participating in this strike for their skill and their courage," the Defence Secretary added. "Including them were numerous British troops deployed over Christmas and New Year. This operation, to eliminate militants who endanger our security, shows how our armed forces are always on standby, all year round, protecting the UK domestically and powerful internationally."
In December, the US military conducted what it called a "major assault" on IS targets in Syria, following an attack claimed the lives of two American soldiers and a civilian linguist in the Palmyra area.
The U.N. says IS still maintains roughly 5-7 thousand militants in both countries.